From 2013 to 2017, people tried to commit suicide using gabapentin nearly 42,000 times, and thousands more abused or misused the substance.
In most cases—nearly 70 percent—the poisoned individuals took a combination of gabapentin and other drugs.
“It’s rare, but overdose from large quantities of gabapentin or baclofen can be fatal,” Reynolds told me via email.
Reynolds’s study and others suggest that doctors’ long struggle to find a safe, reliable treatment for chronic pain is far from over.
And patients who are taking gabapentin should avoid mixing it with other drugs, especially depressants such as alcohol and opioids.

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