It will indicate whether the 98-member Progressive Caucus, which grew in size this year, is willing and able to fight for policies it believes in.
Pelosi is hoping to move quickly to a floor vote to satisfy a major 2018 campaign pledge that Democrats would work to lower drug prices.
Pressure on House Democrats to approve the legislation is compounded by the naming of it after the late revered Cummings, who died of health complications in October.
There are 233 Democrats in the House of Representatives, and Pelosi needs 216 if everybody votes.
Progressive caucus leaders would also rather see the noninterference clause stricken entirely, giving more flexibility to government officials to expand the scope of negotiations.

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